MICCAI Workshop on: Biophotonics Imaging for Diagnostics and Treatment

This paper describes a novel method for quantitative interpretation of multispectral images. By constructing an optical model of a tissue and by modelling the image formation process we predict the spectral composition of light remitted from the tissue. The parameters characterising the tissue are varied to represent the entire range of tissue instances. The modelling of image formation is used in place of statistical modelling in which training is performed using measured data with known parameterisation. In this way the method overcomes a common problem in medical imaging where “ground truth” data can be impossible to obtain. The paper shows application of the method to the recovery of histological parameters characterising the skin, the eye and the colon.